Two-site immunoradiometric assay for adrenocorticotrophin: a cautionary study about the reactivity to its precursor molecules.

@article{Fukata1989TwositeIA,
  title={Two-site immunoradiometric assay for adrenocorticotrophin: a cautionary study about the reactivity to its precursor molecules.},
  author={J Fukata and Yuichiro Naitoh and Takeshi Usui and S Nakaishi and Yoshikatsu Nakai and Hiroo Imura},
  journal={Endocrinologia japonica},
  year={1989},
  volume={36 1},
  pages={155-61}
}
The specificity of a "two-site" immunoradiometric assay (IRMA) has been reevaluated by examining its ability to detect heterogeneous adrenocorticotrophin-like immunoreactivity (ACTH-LI) separated by gel column chromatography. Plasma samples from patients with Addison's disease, Nelson's syndrome and ectopic ACTH syndrome and tissue extract of human anterior pituitary were subjected to ACTH-IRMA and the levels of ACTH-LI were compared with those measured by conventional ACTH-radioimmunoassay… CONTINUE READING

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