Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus.

@article{Dalfonso2005TwoSP,
  title={Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus.},
  author={Sandra D'alfonso and Nadia Barizzone and Mara Giordano and Annalisa Chiocchetti and Corrado Magnani and Luca Castelli and Manuela Indelicato and Francesca Giacopelli and Maurizio Marchini and Raffaella Scorza and Maria Giovanna Danieli and Marida Cappelli and Sergio Migliaresi and B Bigliardo and Maria Grazia Sabbadini and Elena M. Baldissera and Mauro Galeazzi and G D Sebastiani and Giovanni Minisola and Roberto Ravazzolo and Umberto Dianzani and Patricia Momigliano-Richiardi},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 2},
  pages={539-47}
}
OBJECTIVE To test the association of osteopontin (OPN) polymorphisms with systemic lupus erythematosus (SLE). METHODS The coding 5' and 3' flanking regions of the OPN gene were scanned for polymorphisms by denaturing high-performance liquid chromatography. A case-control association study was performed in 394 Italian SLE patients and 479 matched controls. OPN serum levels were determined by enzyme-linked immunosorbent assay in 40 patients and 124 controls, and the mean levels were compared… CONTINUE READING

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