Two signals are required for negative selection of CD4+CD8+ thymocytes.

Abstract

Recent results indicate that two signals are required for activation of mature T cells. The first is delivered through the TCR, and the second is delivered through receptors that bind various ligands expressed on APC. For example, it has been shown that B7/BB1, which is expressed on many APC, can costimulate T cell activation by binding to CD28 or CTLA4… (More)

Topics

Cite this paper

@article{Page1993TwoSA, title={Two signals are required for negative selection of CD4+CD8+ thymocytes.}, author={Dawne M. Page and L P Kane and Janet Allison and Susan Hedrick}, journal={Journal of immunology}, year={1993}, volume={151 4}, pages={1868-80} }