Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity.

@article{Casal2006TwoSM,
  title={Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity.},
  author={Jos{\'e} Casal and Peter A Lawrence and Gary Struhl},
  journal={Development},
  year={2006},
  volume={133 22},
  pages={4561-72}
}
Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed. The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems… CONTINUE READING
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