Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.

@article{Shinohara2012TwoRC,
  title={Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.},
  author={Kyosuke Shinohara and Aiko Kawasumi and Atsuko Takamatsu and Satoko Yoshiba and Yanick Botilde and Noboru Motoyama and Walter Reith and B{\'e}n{\'e}dicte Durand and Hidetaka Shiratori and Hiroshi Hamada},
  journal={Nature communications},
  year={2012},
  volume={3},
  pages={622}
}
Determination of left-right asymmetry in mouse embryos is achieved by a leftward fluid flow (nodal flow) in the node cavity that is generated by clockwise rotational movement of 200-300 cilia in the node. The precise action of nodal flow and how much flow input is required for the robust read-out of left-right determination remains unknown. Here we show that a local leftward flow generated by as few as two rotating cilia is sufficient to break left-right symmetry. Quantitative analysis of fluid… CONTINUE READING
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