Two roles for Rad 50 in telomere maintenance

  title={Two roles for Rad 50 in telomere maintenance},
  author={J Vannier and Annie Depeiges and Charles White and Maria Eugenia Gallego},
We describe two roles for the Rad50 protein in telomere maintenance and the protection of chromosome ends. Using fluorescence in situ hybridisation (FISH) and fibreFISH analyses, we show that absence of AtRad50 protein leads to rapid shortening of a subpopulation of chromosome ends and subsequently chromosome-end fusions lacking telomeric repeats. In the absence of telomerase, mutation of atrad50 has a synergistic effect on the number of chromosome end fusions. Surprisingly, this ‘deprotection… CONTINUE READING
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