Two rights make a wrong: human left-right malformations.

  title={Two rights make a wrong: human left-right malformations.},
  author={Brett Casey},
  journal={Human molecular genetics},
  volume={7 10},
Like all vertebrates, humans establish anatomical left-right asymmetry during embryogenesis. Variation from this normal arrangement (situs solitus) results in heterotaxy, expressed either as randomization (situs ambiguus) or complete reversal (situs inversus) of normal organ position. Familial heterotaxy occurs with autosomal dominant, recessive and X-linked inheritance. All possible situs variants, solitus, ambiguus and inversus, can appear among some heterotaxy families. Positional cloning… CONTINUE READING

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