Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation.

@article{Moura2015TwoRT,
  title={Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation.},
  author={Danielle Maria Nascimento Moura and Christian Robottom Reis and Camila dos Santos Xavier and Tamara D C da Costa Lima and Rodrigo Leme Pinto Lima and Mark Carrington and Osvaldo P de Melo Neto},
  journal={RNA biology},
  year={2015},
  volume={12 3},
  pages={
          305-19
        }
}
In higher eukaryotes, eIF4A, eIF4E and eIF4G homologues interact to enable mRNA recruitment to the ribosome. eIF4G acts as a scaffold for these interactions and also interacts with other proteins of the translational machinery. Trypanosomatid protozoa have multiple homologues of eIF4E and eIF4G and the precise function of each remains unclear. Here, 2 previously described eIF4G homologues, EIF4G3 and EIF4G4, were further investigated. In vitro, both homologues bound EIF4AI, but with different… CONTINUE READING
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