Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites.

@article{Kakule2013TwoRP,
  title={Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites.},
  author={Thomas B. Kakule and Debosmita Sardar and Zhenjian Lin and Eric W. Schmidt},
  journal={ACS chemical biology},
  year={2013},
  volume={8 7},
  pages={
          1549-57
        }
}
Equisetin synthetase (EqiS), from the filamentous fungus Fusarium heterosporum ATCC 74349, was initially assigned on the basis of genetic knockout and expression analysis. Increasing inconsistencies in experimental results led us to question this assignment. Here, we sequenced the F. heterosporum genome, revealing two hybrid polyketide-peptide proteins that were candidates for the equisetin synthetase. The surrounding genes in both clusters had the needed auxiliary genes that might be… 

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