Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo.

@article{Herbrand1998TwoRG,
  title={Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo.},
  author={Heike Herbrand and Savy Guthrie and Thorsten Hadrys and Steffen Hoffmann and Hans Henning Arnold and Silke Rinkwitz-Brandt and Eva Bober},
  journal={Development},
  year={1998},
  volume={125 4},
  pages={645-54}
}
The early stages of otic placode development depend on signals from neighbouring tissues including the hindbrain. The identity of these signals and of the responding placodal genes, however, is not known. We have identified a chick homeobox gene cNkx5-1, which is expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle. In a series of heterotopic transplantation experiments, we demonstrate that… CONTINUE READING