Two regulatory domains flank the mouse H19 gene.

  title={Two regulatory domains flank the mouse H19 gene.},
  author={H Yoo-Warren and V Pachnis and Robert S. Ingram and Shirley M. Tilghman},
  journal={Molecular and cellular biology},
  volume={8 11},
The mouse H19 gene was identified by virtue of its coordinate regulation with the mouse alpha-fetoprotein gene. Both genes are expressed in the fetal liver, gut, and visceral endoderm of the yolk sac and are repressed shortly after birth in the liver and gut. They are both under the control of two trans-acting loci: raf, which affects the adult basal levels of the two mRNAs, and Rif, which affects their inducibility during liver regeneration. One crucial difference between the two genes is the… CONTINUE READING


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