Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels.

@article{Nakai1998TwoRO,
  title={Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels.},
  author={Junichi Nakai and Naotaka Sekiguchi and Thomas A Rando and Paul D. Allen and Kurt G Beam},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 22},
  pages={13403-6}
}
Ryanodine receptors (RyRs) are present in the endoplasmic reticulum of virtually every cell type and serve critical roles, including excitation-contraction (EC) coupling in muscle cells. In skeletal muscle the primary control of RyR-1 (the predominant skeletal RyR isoform) occurs via an interaction with plasmalemmal dihydropyridine receptors (DHPRs), which function as both voltage sensors for EC coupling and as L-type Ca2+ channels (Rios, E., and Brum, G. (1987) Nature 325, 717-720). In… CONTINUE READING