Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP

@article{Hensley2010TwoPA,
  title={Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP},
  author={Christopher Thomas Hensley and Olga K. Kamneva and Karen M. Levy and Stephanie K. Labahn and Lia A A Africa and Helen J Wing},
  journal={Archives of Microbiology},
  year={2010},
  volume={193},
  pages={263-274}
}
The Shigella flexneri outer membrane protease IcsP proteolytically cleaves the actin-based motility protein IcsA from the bacterial surface. The icsP gene is monocistronic and lies downstream of an unusually large intergenic region on the Shigella virulence plasmid. In silico analysis of this region predicts a second transcription start site 84 bp upstream of the first. Primer extension analyses and beta-galactosidase assays demonstrate that both transcription start sites are used. Both… CONTINUE READING
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