Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides.

@article{Spindel1986TwoPF,
  title={Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides.},
  author={E. R. Spindel and M D Zilberberg and Joel Francis Habener and William Wei Lim Chin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 1},
  pages={
          19-23
        }
}

• E. R. Spindel, M D Zilberberg, +1 author William Wei Lim Chin
• Published 1986 in
  Proceedings of the National Academy of Sciences…

In our studies on the molecular biology of human gastrin-releasing peptide (GRP), we have discovered an example of a change in translational reading frame apparently produced through alternative RNA splicing. Complementary DNAs prepared from a pulmonary carcinoid tumor rich in GRP immunoreactivity had one of two different-sized internal DNA fragments after digestion with the restriction enzyme Pvu II. Nucleotide sequences of the two DNA fragments were identical except for 19 additional… CONTINUE READING

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