Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.

@article{Gruss2004TwoporedomainKC,
  title={Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.},
  author={Marco Gruss and Trevor J Bushell and Damian P. Bright and William Robert Lieb and Alistair Mathie and Nicholas P Franks},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 2},
  pages={443-52}
}
Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological profile. Whereas the molecular basis for their anesthetic actions remains unclear, they behave very differently to most other general anesthetics in that they have little or no effect on GABAA receptors, yet strongly inhibit the N-methyl-d-aspartate subtype of glutamate receptors. Here we show that certain members of the two-pore-domain K+ channel superfamily may represent an important new target… CONTINUE READING

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