Two-pore channels mediated receptor-operated Ca2+ entry in pulmonary artery smooth muscle cells in response to hypoxia.

@article{Jiang2018TwoporeCM,
  title={Two-pore channels mediated receptor-operated Ca2+ entry in pulmonary artery smooth muscle cells in response to hypoxia.},
  author={Yongliang Jiang and Yumin Zhou and Gongyong Peng and Heshen Tian and Dan Pan and Lei Liu and Xing Yang and Chao Li and Wen Li and Ling Chen and Pixin Ran and Aiguo Dai},
  journal={The international journal of biochemistry & cell biology},
  year={2018},
  volume={97},
  pages={
          28-35
        }
}
The aim of this study was to investigate the influence of two-pore channels mediated receptor-operated Ca2+ entry on pulmonary arterial smooth muscle cell (PASMC) under hypoxia conditions. PASMCs were separated using the direct adherent culture method. The cultured cells were observed under optic microscope and the phenotypes of cells were identified by immunohistochemistry. The expression of NAADP was examined by ELISA. CaN, TPC1, TPC2 and NFATc3 protein levels were examined using Western… CONTINUE READING
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