Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome.

@article{Polman2013TwoPO,
  title={Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome.},
  author={J. Polman and E. D. de Kloet and N. Datson},
  journal={Endocrinology},
  year={2013},
  volume={154 5},
  pages={
          1832-44
        }
}
In the present study, genomic binding sites of glucocorticoid receptors (GR) were identified in vivo in the rat hippocampus applying chromatin immunoprecipitation followed by next-generation sequencing. We identified 2470 significant GR-binding sites (GBS) and were able to confirm GR binding to a random selection of these GBS covering a wide range of P values. Analysis of the genomic distribution of the significant GBS revealed a high prevalence of intragenic GBS. Gene ontology clusters… Expand
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  • K. Mifsud, J. Reul
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2016
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