Two populations of AChR in rat myotubes have different degradation rates and responses to cAMP.

@article{OMalley1993TwoPO,
  title={Two populations of AChR in rat myotubes have different degradation rates and responses to cAMP.},
  author={James P. O'Malley and Lee L Rubin and Miriam M. Salpeter},
  journal={Experimental cell research},
  year={1993},
  volume={208 1},
  pages={44-7}
}
Acetylcholine receptors (AChRs) of rat muscle cells grown in culture for 4 days were labeled with 125I-alpha-bungarotoxin and their degradation rate measured. Two AChR populations, a rapidly degrading one (Rr,t1/2 approximately 1 day) and a slowly degrading one (Rs, t1/2 approximately 4 days) were identified at a ratio of approximately 9 to 1. The degradation rate of the Rs was slowed to a t1/2 of approximately 10 days by cAMP while that of the Rr remained unchanged. These data provide further… CONTINUE READING