Two-photon uncaging: New prospects in neuroscience and cellular biology.

  title={Two-photon uncaging: New prospects in neuroscience and cellular biology.},
  author={David Warther and Sylvestre Gug and Alexandre Specht and Fr{\'e}d{\'e}ric Bolze and J-F Nicoud and Alexandre Mourot and Maurice Goeldner},
  journal={Bioorganic & medicinal chemistry},
  volume={18 22},
An uncaging process refers to a fast and efficient release of a biomolecule after photochemical excitation from a photoactivatable precursor. Two-photon excitation produces excited states identical to standard UV excitation while overcoming major limitations when dealing with biological materials, like spatial resolution, tissue penetration and toxicity and has therefore been applied to the uncaging of different biological effectors. A literature survey of two-photon uncaging of biomolecules is… CONTINUE READING

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