Two phosphatase sites on the Ca2+ channel affecting different kinetic functions.

@article{Ono1993TwoPS,
  title={Two phosphatase sites on the Ca2+ channel affecting different kinetic functions.},
  author={Katsushige Ono and Harry A. Fozzard},
  journal={The Journal of physiology},
  year={1993},
  volume={470},
  pages={73-84}
}
1. Changes in dihydropyridine-sensitive (L-type) Ca2+ channel kinetics were studied after prolongation of intrinsic phosphorylated time by the phosphatase inhibitor okadaic acid (OA) in cell-attached patches made from single isolated rabbit ventricular myocytes, using barium as the charge carrier. 2. At low concentrations (0.001-1 microM), OA decreased the number of sweeps without openings, while open duration was not changed. However, when cells were pretreated by a membrane-permeant cyclic… CONTINUE READING

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