Two phenotypically compensating isocitrate dehydrogenases in Ralstonia eutropha.

@article{Wang2003TwoPC,
  title={Two phenotypically compensating isocitrate dehydrogenases in Ralstonia eutropha.},
  author={Zheng-xiang Wang and Christian O. Br{\"a}mer and Alexander Steinb{\"u}chel},
  journal={FEMS microbiology letters},
  year={2003},
  volume={227 1},
  pages={
          9-16
        }
}
The tricarboxylic acid (TCA) cycle enzyme isocitrate dehydrogenase (IDH) and the glyoxylate bypass enzyme isocitrate lyase are involved in catabolism of isocitrate and play a key role in controlling the metabolic flux between the TCA cycle and the glyoxylate shunt. Two IDH genes icd1 and icd2 of Ralstonia eutropha HF39, encoding isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2), were identified and characterized. Icd1 was functionally expressed in Escherichia coli, whereas… CONTINUE READING

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