Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene.

@article{Mononen2000TwoPO,
  title={Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene.},
  author={Nina Mononen and Kirsi Syrj{\"a}koski and Mika Matikainen and Teuvo L. J. Tammela and Johanna Schleutker and Olli Kallioniemi and Jan Trapman and Pasi A. Koivisto},
  journal={Cancer research},
  year={2000},
  volume={60 22},
  pages={
          6479-81
        }
}
Mutations of the androgen receptor (AR) gene have been reported in prostate cancer, usually from tumor tissue specimens from late-stage, androgen-independent cancer. Occasionally, germ-line mutations have been found, but a link between AR mutations and predisposition to human prostate cancer has not been firmly established. Recently, two independent studies reported the same germ-line mutation at codon 726 in exon E (CGC to CTC) in two apparently unrelated Finnish prostate cancer patients. This… CONTINUE READING

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