Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients.

@article{Breen2004TwoPA,
  title={Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients.},
  author={Gerome Breen and Adrian J Harwood and Kathryn M. Gregory and Maggie Sinclair and David Collier and David St Clair and Robin S. B. Williams},
  journal={Bipolar disorders},
  year={2004},
  volume={6 2},
  pages={156-61}
}
BACKGROUND Inhibition of prolyl oligopeptidase (PO) in primary neuronal cultures has been shown to reverse the effect of the common mood-stabilizers lithium, valproic acid and carbamazepine. In clinical studies, abnormal plasma PO activity has been associated with bipolar disorder (BD) and schizophrenia. However, this association is complicated by the discovery in bovine plasma of a Z-Pro-prolinal-insensitive peptidase (ZIP), a novel enzyme that cleaves the same substrate as PO. METHODS We… CONTINUE READING

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