Two pathways of rod photoreceptor cell death induced by elevated cGMP.

@article{Wang2017TwoPO,
  title={Two pathways of rod photoreceptor cell death induced by elevated cGMP.},
  author={Tian Wang and Stephen H Tsang and Jeannie Chen},
  journal={Human molecular genetics},
  year={2017},
  volume={26 12},
  pages={
          2299-2306
        }
}
Cyclic-GMP is a second messenger in phototransduction, a G-protein signaling cascade that conveys photon absorption by rhodopsin to a change in current at the rod photoreceptor outer segment plasma membrane. Basal cGMP level is strictly controlled by the opposing actions of phosphodiesterase (PDE6) and retinal guanylyl cyclases (GCs), and mutations in genes that disrupt cGMP homeostasis leads to retinal degeneration in humans through mechanisms that are incompletely understood. The purpose of… CONTINUE READING