Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets.

@article{Rosado2004TwoPF,
  title={Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets.},
  author={Juan Antonio Rosado and Jos{\'e} Javier L{\'o}pez and A G S Harper and Matthew Thomas Harper and Pedro Cosme Redondo and Jos{\'e} Antonio Pariente and Stewart O. Sage and Gin{\'e}s M Salido},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={
          29231-5
        }
}
A major pathway for stimulated Ca(2+) entry in non-excitable cells is activated following depletion of intracellular Ca(2+) stores. Secretion-like coupling between elements in the plasma membrane (PM) and Ca(2+) stores has been proposed as the most likely mechanism to activate this store-mediated Ca(2+) entry (SMCE) in several cell types. Here we identify two mechanisms for SMCE in human platelets activated by depletion of two independent Ca(2+) pools, which are differentially modulated by the… CONTINUE READING
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