Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

@article{Johansen1994TwoPF,
  title={Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.},
  author={F E Johansen and Ron Prywes},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 9},
  pages={5920-8}
}
The c-fos serum response element (SRE) is necessary and sufficient for induction of the c-fos gene in response to serum and growth factors. This activation is dependent upon serum response factor (SRF), a transcriptional activator which binds the SRE. A factor, p62TCF, which binds in conjunction with SRF to the SRE and which is activated by mitogen-activated protein kinase, has also been implicated in c-fos regulation. By using a reporter gene system with weak SRE mutations that is dependent… CONTINUE READING

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