Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor.

@article{Berg2002TwoPP,
  title={Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor.},
  author={P. M. Van Den Berg and Ingemar Pongratz},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 35},
  pages={32310-9}
}
The dioxin receptor is a ligand-dependent transcription factor that mediates the biological effects of dioxin and related environmental pollutants. In the absence of ligand the receptor is present in the cytoplasmic compartment of the cell associated with the hsp90-dependent chaperone complex. This complex regulates several functions of the receptor such as ligand binding and nuclear import. Furthermore, intracellular localization of the receptor is modulated by multiple factors such as the… CONTINUE READING