Two parallel pathways in the kinetic sequence of the dihydrofolate reductase from Mycobacterium tuberculosis.

@article{Czekster2011TwoPP,
  title={Two parallel pathways in the kinetic sequence of the dihydrofolate reductase from Mycobacterium tuberculosis.},
  author={Clarissa M Czekster and An Vandemeulebroucke and John S Blanchard},
  journal={Biochemistry},
  year={2011},
  volume={50 32},
  pages={7045-56}
}
Dihydrofolate reductase from Mycobacterium tuberculosis (MtDHFR) catalyzes the NAD(P)H-dependent reduction of dihydrofolate, yielding NAD(P)(+) and tetrahydrofolate, the primary one-carbon unit carrier in biology. Tetrahydrofolate needs to be recycled so that reactions involved in dTMP synthesis and purine metabolism can be maintained. Previously, steady… CONTINUE READING