Two oral HBx vaccines delivered by live attenuated Salmonella: both eliciting effective anti-tumor immunity.

@article{Wang2008TwoOH,
  title={Two oral HBx vaccines delivered by live attenuated Salmonella: both eliciting effective anti-tumor immunity.},
  author={Ye-jun Wang and Yan Li Hou and He Huang and Gui-Rong Liu and Aaron P. White and Shu-lin Liu},
  journal={Cancer letters},
  year={2008},
  volume={263 1},
  pages={67-76}
}
Live attenuated bacteria have great potential for use in vaccine development due to several unique advantages, including stable antigen expression, effective antigen presentation, convenient and inexpensive delivery, and low cost of vaccine production. In this study, we expressed hepatitis B virus x gene (HBx) on mouse melanoma cells as the target antigen and constructed Salmonella-based HBx vaccines by two strategies, i.e., recombinant eukaryotic plasmid encoding HBx and a recombinant… CONTINUE READING