Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells.

@article{FourmentrauxNeves2008TwoOS,
  title={Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells.},
  author={Emmanuelle Fourmentraux-Neves and Abdelali Jalil and Sylvie Da Rocha and Christophe Pichon and Salem Chouaib and Georges Bismuth and Anne Caignard},
  journal={Blood},
  year={2008},
  volume={112 6},
  pages={2381-9}
}
Inhibitory killer Ig-like receptors (KIR), expressed by human natural killer cells and effector memory CD8(+) T-cell subsets, bind HLA-C molecules and suppress cell activation through recruitment of the Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1). To further analyze the still largely unclear role of inhibitory KIR receptors on CD4(+) T cells, KIR2DL1 transfectants were obtained from a CD4(+) T-cell line and primary cells. Transfection of CD4(+) T cells with KIR2DL1… CONTINUE READING