Two olfactory marker proteins in Xenopus laevis

@article{Roessler1998TwoOM,
  title={Two olfactory marker proteins in Xenopus laevis},
  author={Patricia Roessler and Mario Mezler and Heinz Breer},
  journal={Journal of Comparative Neurology},
  year={1998},
  volume={395}
}
Mature olfactory receptor neurons of mammals are characterized by the expression of the highly conserved olfactory marker protein (OMP) encoded by single copy genes. In Xenopus laevis, two homologous genes encoding olfactory marker proteins have been identified that share a sequence identity with mammalian OMPs of about 50%. Sequence comparison revealed significant variability in the N‐terminus and C‐terminus regions; in contrast, two internal domains were highly conserved between amphibian and… 
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This study finds distinct expression patterns of zebrafish OMP1 and 2 at the tissue and cellular level and provides a good example for analyzing a functional subdivision of the teleost OE and eyes as revealed by 3R-derived paralogs of OMPs.
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References

SHOWING 1-10 OF 19 REFERENCES
Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
TLDR
Observations provide strong support for the conclusion that OMP is a novel modulatory component of the odor detection/signal transduction cascade and postsynaptic changes in gene expression induced by peripheral olfactory deafferentation or naris blockade are confirmed.
Olfactory marker protein mRNA is found in axons of olfactory receptor neurons
TLDR
It is hypothesized that the immature nature of the cytoskeleton and, specifically, the lack of tightly bundled microtubules allows transport of particular mRNAs in olfactory receptor axons.
Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization.
TLDR
The OMP gene from human and mouse is cloned and conservation of gene structure, protein sequence, and Olf-1 and upstream binding region (UBE) regulatory domains are demonstrated, allowing additional insight into mechanisms that may participate in the stringent regulation of the expression of this neuronal-specific protein.
Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice.
TLDR
Functional OMP regulatory sequences were demonstrated in transgenic mice and showed the absence of introns and the lack of CAAT and TATA boxes in the 5' flanking region.
Immunocytochemical identification of primary olfactory afferents in rainbow trout
TLDR
It is likely that the organization of afferents in the trout olfactory bulb is similarly well regulated during normal receptor cell replacement.
Molecular Cloning of Olfactory-Specific Gene Products
TLDR
The major thrust of this chapter is to consider the use of biochemical and molecular biological approaches in the study of the regulation of specific gene expression in the peripheral olfactory system.
Olfactory neuron-specific protein is translated from a large poly(A)+ mRNA.
TLDR
In vitro synthesized OMP is synthesized directly without the intermediate formation of a larger polypeptide precursor, indicating that OMP mRNA contains untranslated regions that are four to five times larger than the coding region.
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