Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin.

  title={Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin.},
  author={Katrin Jungmann and Dimas F Praditya and Klaus Gerth and Volker Huch and Daniel Krug and William Fenical and Rolf M{\"u}ller},
  journal={ACS chemical biology},
  volume={10 11},
Chlorotonil A is a novel polyketide isolated from the myxobacterium Sorangium cellulosum So ce1525 that features a unique gem-dichloro-1,3-dione moiety. It exhibits potent bioactivity, most notably against the problematic malaria pathogen Plasmodium falciparum in the nanomolar range. In addition, strong antibacterial and moderate antifungal activity were determined. The outstanding biological activity of chlorotonil A as well as its unusual chemical structure triggered our interest in… CONTINUE READING

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