Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man

@article{Nathrath2002TwoNT,
  title={Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man},
  author={Michaela Nathrath and Virginija Kuosaite and Michael Rosemann and Markus Kremer and Christopher Poremba and Shigeharu Wakana and Masayuki Yanagi and Walter B. J. Nathrath and Heinz Hoefler and Kenji Imai and Michael J Atkinson},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5975-5980}
}
We have performed a comparative study of allelic imbalances in human and murine osteosarcomas to identify genetic changes critical for osteosarcomagenesis. Two adjacent but discrete loci on mouse chromosome 9 were found to show high levels of allelic imbalance in radiation-induced osteosarcomas arising in (BALB/c×CBA/CA) F1 hybrid mice. The syntenic human chromosomal regions were investigated in 42 sporadic human osteosarcomas. For the distal locus (OSS1) on mouse chromosome 9 the syntenic… CONTINUE READING

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