Two novel human NUMB isoforms provide a potential link between development and cancer

@inproceedings{Karaczyn2010TwoNH,
  title={Two novel human NUMB isoforms provide a potential link between development and cancer},
  author={Aldona A. Karaczyn and Mahmud Bani-Yaghoub and Roger G. Tremblay and Chris Kubu and Rebecca A. Cowling and Tamara L. Adams and Igor Prudovsky and Douglas B. Spicer and Robert E Friesel and Calvin P. H. Vary and Joseph M. Verdi},
  booktitle={Neural Development},
  year={2010}
}
We previously identified four functionally distinct human NUMB isoforms. Here, we report the identification of two additional isoforms and propose a link between the expression of these isoforms and cancer. These novel isoforms, NUMB5 and NUMB6, lack exon 10 and are expressed in cells known for polarity and migratory behavior, such as human amniotic fluid cells, glioblastoma and metastatic tumor cells. RT-PCR and luciferase assays demonstrate that NUMB5 and NUMB6 are less antagonistic to NOTCH… CONTINUE READING
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