Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii.

@article{Sun2014TwoNC,
  title={Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii.},
  author={Yihang Sun and Meicheng Wang and Quanhui Ren and S. Li and Jing Xu and Y. Ohizumi and Chunfeng Xie and D. Jin and Yuanqiang Guo},
  journal={Fitoterapia},
  year={2014},
  volume={95},
  pages={
          229-33
        }
}
  • Yihang Sun, Meicheng Wang, +6 authors Yuanqiang Guo
  • Published 2014
  • Chemistry, Medicine
  • Fitoterapia
  • Nerve growth factor (NGF) and analog reagents to promote the neurite outgrowth of nerve cells against the neuron degeneration are expected to be potentially useful for the medical treatment of Alzheimer's disease. In our focus on the discovery of bioactive diterpenes, we investigated the chemical constituents of the plant Croton yanhuii. This investigation led to the isolation and identification of two novel clerodane diterpenes (1 and 2). Their structures were elucidated on the basis of… CONTINUE READING
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