Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii.

  title={Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii.},
  author={Yihang Sun and Meicheng Wang and Quanhui Ren and S. Li and Jing Xu and Y. Ohizumi and Chunfeng Xie and D. Jin and Yuanqiang Guo},
  • Yihang Sun, Meicheng Wang, +6 authors Yuanqiang Guo
  • Published 2014
  • Chemistry, Medicine
  • Fitoterapia
  • Nerve growth factor (NGF) and analog reagents to promote the neurite outgrowth of nerve cells against the neuron degeneration are expected to be potentially useful for the medical treatment of Alzheimer's disease. In our focus on the discovery of bioactive diterpenes, we investigated the chemical constituents of the plant Croton yanhuii. This investigation led to the isolation and identification of two novel clerodane diterpenes (1 and 2). Their structures were elucidated on the basis of… CONTINUE READING
    20 Citations

    Figures, Tables, and Topics from this paper.

    Characterization and Biological Evaluation of Diterpenoids from Casearia graveolens.
    • 15
    Bioactive clerodane diterpenoids from the twigs of Casearia balansae.
    • 24
    Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects.
    • 12
    Clerodane diterpenes: sources, structures, and biological activities.
    • 68
    • PDF
    New clerodane diterpenoids from Croton crassifolius.
    • 20
    Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review
    • 85
    • PDF
    Chemical Constituents from Croton Species and Their Biological Activities
    • 22
    • Highly Influenced
    • PDF


    Novel NGF-potentiating limonoids from the fruits of Melia toosendan.
    • 14
    Anti-inflammatory diterpenoids from Croton tonkinensis.
    • 40
    Evidence for Nerve Growth Factor‐Potentiating Activities of the Nonpeptidic Compound SR 57746A in PC12 Cells
    • 62
    Sesquiterpenes inhibiting NO production from Celastrus orbiculatus.
    • 10
    ent-Kaurane diterpenoids from Croton tonkinensis stimulate osteoblast differentiation.
    • 23
    Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana.
    • 22
    Diterpenoids from Cascarilla (Croton eluteria Bennet).
    • 10
    Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion.
    • 8
    Cytotoxic labdane diterpenoids from Croton oblongifolius.
    • 34