Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.

@article{Pepper2011TwoNA,
  title={Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.},
  author={Chris Pepper and Jassem G. Mahdi and Andrea G S Buggins and Saman Hewamana and Elisabeth J. Walsby and E S Mahdi and A Al-Haza'a and Ali Jassem Mahdi and Thet Thet Lin and Lawrence Pearce and Llinos W. Morgan and Ifor Delme Bowen and Paul Brennan and Christopher Fegan},
  journal={Cell proliferation},
  year={2011},
  volume={44 4},
  pages={380-90}
}
OBJECTIVES Non-steroidal anti-inflammatory drugs have been shown to induce apoptosis in primary B-cell chronic lymphocytic leukaemia (CLL) cells, but the molecular mechanisms that underpin this observation have not been fully elucidated. Here, we have analysed the effect two novel aspirin analogues, 2-hydroxy benzoate zinc (2HBZ) and 4-hydroxy benzoate zinc… CONTINUE READING