Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

@article{Gether1993TwoNT,
  title={Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.},
  author={Ulrik Gether and Yoshifumi Yokota and Xavier Emonds-Alt and J. C. Breli{\`e}re and John A. Lowe and R. Michael Snider and Shigetada Nakanishi and Thue W. Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 13},
  pages={6194-8}
}
The molecular mechanism of action for two chemically distinct and highly selective, nonpeptide antagonists, CP-96,345 and SR-48,968, was studied by development of a series of chimeric constructs between their respective target receptors, the NK1 (substance P) and NK2 (neurokinin A) receptors. The binding affinities of the natural peptide ligands, substance P and neurokinin A, were not affected by exchanging almost the entire C-terminal half of the NK1 receptor with the corresponding segment of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…