Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner

@article{Chen2006TwoNB,
  title={Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner},
  author={Ping-Yen Chen and W W Chang and Ruey Hwang Chou and Yiu-Kay Lai and Sen Lin and Chia-Yi Chi and Cheng-Wen Wu},
  journal={BMC Molecular Biology},
  year={2006},
  volume={8},
  pages={2 - 2}
}
Despite of the fact that mammalian genomes are far more spacious than prokaryotic genomes, recent nucleotide sequencing data have revealed that many mammalian genes are arranged in a head-to-head orientation and separated by a small intergenic sequence. Extensive studies on some of these neighboring genes, in particular homologous gene pairs, have shown that these genes are often co-expressed in a symmetric manner and regulated by a shared promoter region. Here we report the identification of… CONTINUE READING

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