Two new diterpenoids from Excoecaria acerifolia

  title={Two new diterpenoids from Excoecaria acerifolia},
  author={Xing-de Wu and Lan-Chun Zhang and Juan He and Gentao Li and Lin-fen Ding and Xiu Gao and Liao-Bin Dong and Liu-Dong Song and Yan Chun Li and Qin‐Shi Zhao},
  journal={Journal of Asian Natural Products Research},
  pages={151 - 157}
A new tigliane diterpenoid, acerifolin A (1), and a new isopimarane diterpenoid, acerifolin B (2), together with two known compounds, were isolated from Excoecaria acerifolia. Their structures were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for cytotoxicity against five human cancer cell lines with cisplantin as a positive control. 

Sesquiterpenoids from the twigs and leaves of Fokienia hodginsii

The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, including 1D and 2D NMR methods and evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines.

Diterpenes and Their Derivatives as Potential Anticancer Agents

Diterpenes may be one of the lead molecules in the treatment of cancer, acting in the different pathways, and some are already under clinical trials, while others are in the nonclinical and/or pre‐clinical trials.

Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity

The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β,

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

A hot water extract of the leaves of C. takesimana exhibited a significant inhibitory effect on lipopolysaccharide (LPS)-stimulated prostaglandin E2 (PGE2) production, which led to the isolation of three new neolignan glucosides, campanulalignans A–C (1–3), with 15 known compounds (4–18).

Diterpenoids of terrestrial origin.

This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products.

Boesenberols, Pimarane Diterpenes with TRAIL-Resistance-Overcoming Activity from Boesenbergia pandurata.

In a screening program on natural resources with the ability to abrogate TRAIL resistance, the bioassay-guided fractionation of Boesenbergia pandurata rhizomes resulted in the isolation of 17 pimarane diterpenes and a monoterpene.

Tigliane diterpenoids from the Euphorbiaceae and Thymelaeaceae families.

Families Hong-Bing Wang,*, Xiao-Yang Wang,†,‡ Li-Ping Liu,† Guo-Wei Qin, and Ting-Guo Kang are involved in the research.



Pentacyclic triterpenoids from leaves of Excoecaria agallocha.

A new oleanane-type triterpenoid (1) and five known pentacyclic triterpenoids (2-6) were isolated from the leaves of Excoecaria agallocha. Their structures were elucidated by spectroscopic analyses.

Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia together with 16 known compounds and showed antiangiogenic effects and apoptosis-inducing effects on A549 lung cancer cells.

A new antipsychotic effective neolignan fromfirmiana simplex

A new neolignan, named simplidin was isolated from the the n-butanol extract of stem ofFirmiana simplex, together with six known compounds, scopoletin (1), syrigaresinol (2), aquillochin (3),

A new isopimarane-type diterpene and a new natural atisane-type diterpene from Excoecaria agallocha

From the woods of Excoecaria agallocha, a new isopimarane-type diterpene, 3α,11β-dihydroxy-ent-isopimara-8(14),15-dien-2-one (1) and a new natural atisane-type diterpene, 16β-hydroxy-ent-atisan-3-one

New Hepatoprotective Coumarinolignoids from Mallotus apelta

Compounds 3 showed promising hepatoprotective activity against D‐galactosamine‐induced toxicity in WB‐F344 rat hepatic epithelial stem‐like cells and three new coumarinolignoids, malloapelins A–C, were isolated from the roots of Mallotus apelta Muell.

Plant anticancer agents. XIX Constituents of Aquilaria malaccensis.

The stem bark of the Thai tree Aquilaria malaccensis has afforded 1,3-dibehenyl-2-ferulyl glyceride, which is novel, and 12-O-n-deca- 2, 4, 6-trienoylphorbol-13-acetate, a cytotoxic compound which was elucidated by their spectral and chemical parameters.

Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II.

The secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanovl-phorbol-13-acetate.

A novel phorbol ester from Excoecaria agallocha.

The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was

Cassane- and norcassane-type diterpenes of Caesalpinia crista from Myanmar.

Five new cassane-type diterpenes, caesalpinins MA-ME (1-5), and three new norcassane- type diter penes, norcaesalpins MA-MC (6-8), have been isolated from seed kernels of Caesal Pinia crista from Myanmar.

Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata.

Eight new tigliane- and daphnane-type diterpenes were found in Pimelea elongata, and the structures and relative configurations of the new compounds were determined by 1D and 2D NMR spectroscopic studies in combination with MS analyses.