Two new compounds with cytotoxic activity on the human melanoma A375-S2 cells from Daphne giraldii callus cells.

@article{Wang2012TwoNC,
  title={Two new compounds with cytotoxic activity on the human melanoma A375-S2 cells from Daphne giraldii callus cells.},
  author={Li-Bo Wang and Nai-Wei Dong and Zhao-Hua Wu and Li-jun Wu},
  journal={Journal of Asian natural products research},
  year={2012},
  volume={14 11},
  pages={1020-6}
}
Four compounds were isolated from Daphne giraldii callus cells, and their structures were characterized as daphnenone (1), daphnolon (2), R-( - )-1-(4'-hydroxyphenyl)-3-hydroxy-5-phenyl-1,5-pentandione (3), and S-(+)-daphneolone-4'-O-β-d-glucoside (4) on the basis of MS, NMR spectrographic analysis, and chemical methods. All of the four compounds possessed C6-C5-C6 carbon skeleton, and among them, 3 and 4 were two new compounds. In activity screening test, compounds 1, 2, 3, and 4 showed… CONTINUE READING

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