Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity.

@article{Boehm2006TwoMP,
  title={Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity.},
  author={Jannic Boehm and Ingrid Ehrlich and Helen Hsieh and Roberto Malinow},
  journal={Learning & memory},
  year={2006},
  volume={13 5},
  pages={562-5}
}
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity. 

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