Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae.

@article{Torchet1998TwoMF,
  title={Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae.},
  author={Claire Torchet and Claude Jacq and Sylvie Hermann-Le Denmat},
  journal={RNA},
  year={1998},
  volume={4 12},
  pages={
          1636-52
        }
}
  • Claire Torchet, Claude Jacq, Sylvie Hermann-Le Denmat
  • Published in RNA 1998
  • Biology, Medicine
  • The genetic depletion of yeast Rrp5p results in a synthesis defect of both 18S and 5.8S ribosomal RNAs (Venema J, Tollervey D. 1996. EMBO J 15:5701-5714). We have isolated the RRP5gene in a genetic approach aimed to select for yeast factors interfering with protein import into mitochondria. We describe here a striking feature of Rrp5p amino acid sequence, namely the presence of twelve putative S1 RNA-binding motifs and seven tetratricopeptide repeats (TPR) motifs. We have constructed two… CONTINUE READING

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