Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.

@article{Dhauteville2002TwoMG,
  title={Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.},
  author={H. D'hauteville and Shahid Ullah Khan and Duncan J Maskell and Anders Kussak and Andrej Weintraub and J. Edward Mathison and Richard J Ulevitch and Nicole Wuscher and Claude Parsot and Philippe J Sansonetti},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={
          5240-51
        }
}
Shigella flexneri is a Gram-negative pathogen that invades and causes inflammatory destruction of the human colonic epithelium, thus leading to bloody diarrhea and dysentery. A type III secretion system that delivers effector proteins into target eukaryotic cells is largely responsible for cell and tissue invasion. However, the respective role of this invasive phenotype and of lipid A, the endotoxin of the Shigella LPS, in eliciting the inflammatory cascade that leads to rupture and destruction… CONTINUE READING

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