Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.

@article{Svensson1998TwomonthTO,
  title={Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.},
  author={Johan Svensson and Lars L{\"o}nn and Jan oWEN Jansson and Gillian Murphy and Danielle Wyss and D. Krupa and K A Cerchio and Wj Polvino and Beate Gertz and I Boseaus and Lars Olov Sj{\"o}str{\"o}m and B. A. Bengtsson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 2},
  pages={
          362-9
        }
}
Obesity is associated with blunted GH secretion, unfavorable body composition, and increased cardiovascular mortality. The objective of this study was to investigate the effects of oral treatment with the GH secretagogue MK-677 on GH secretion and body composition in otherwise healthy obese males. The study was randomized, double blind, parallel, and placebo controlled. Twenty-four obese males, aged 18-50 yr, with body mass indexes greater than 30 kg/m2 and waist/hip ratios greater than 0.95… CONTINUE READING

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