Two molecules of lobophorolide cooperate to stabilize an actin dimer using both their "ring" and "tail" region.

Actin filament-disrupting marine macrolides are promising templates from which to design therapeutics against cancer and other diseases that co-opt the actin cytoskeleton. Typically, these macrolides form either a 1:1 or 2:1 actin-macrolide complex where their aliphatic side chain, or "tail," has been reported to convey the major determinant of cytotoxicity… (More)