Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle.

@article{Ferreira2004TwoMO,
  title={Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle.},
  author={Miguel Godinho Ferreira and Julia Promisel Cooper},
  journal={Genes & development},
  year={2004},
  volume={18 18},
  pages={2249-54}
}
Several considerations suggest that levels of the two major modes of double-strand break (DSB) repair, homologous recombination (HR), and nonhomologous end joining (NHEJ), are regulated through the cell cycle. However, this idea has not been explicitly tested. In the absence of the telomere-binding protein Taz1, fission yeast undergo lethal telomere fusions via NHEJ. These fusions occur only during periods of nitrogen starvation and fail to accumulate during logarithmic growth, when the… CONTINUE READING