Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals.

  title={Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals.},
  author={Michael A. Cousin and Phillip J Robinson},
  journal={Journal of neurochemistry},
  volume={75 4},
KCl and 4-aminopyridine (4-AP) evoke glutamate release from rat brain cortical nerve terminals by voltage clamping or by Na(+) channel-generated repetitive action potentials, respectively. Stimulation by 4-AP but not KCl is largely mediated by protein kinase C (PKC). To determine whether KCl and 4-AP utilise the same mechanism to release glutamate, we correlated glutamate release with release of the hydrophobic synaptic vesicle (SV) marker FM2-10. A strong correlation was observed for… CONTINUE READING


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