Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis

@article{Iordanov2005TwoMO,
  title={Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis},
  author={Mihail S. Iordanov and Olga P. Ryabinina and Pascal Schneider and Bruce E. Magun},
  journal={Apoptosis},
  year={2005},
  volume={10},
  pages={153-166}
}
Viral double-stranded RNA (dsRNA) is a ubiquitous intracellular “alert signal” used by cells to detect viral infection and to mount anti-viral responses. DsRNA triggers a rapid (complete within 2–4 h) apoptosis in the highly-susceptible HeLa cell line. Here, we demonstrate that the apical event in this apoptotic cascade is the activation of procaspase 8… CONTINUE READING