Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A.

@article{Prabhananda1996TwoMO,
  title={Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A.},
  author={Bala S Prabhananda and Mamata H. Kombrabail},
  journal={Biophysical journal},
  year={1996},
  volume={71 6},
  pages={3091-7}
}
Two rate-limiting mechanisms have been proposed to explain the gramicidin channel facilitated decay of the pH difference across vesicular membrane (delta pH) in the pH region 6-8 and salt (MCI, M+ = K+, Na+) concentration range 50-300 mM. 1) At low pH conditions (approximately 6), H+ transport through the gramicidin channel predominantly limits the delta pH decay rate. 2) At higher pH conditions (approximately 7.5), transport of a deprotonated species (but not through the channel) predominantly… CONTINUE READING