Two mechanisms mediate relaxation by bradykinin of pig coronary artery: NO-dependent and -independent responses.

@article{Cowan1991TwoMM,
  title={Two mechanisms mediate relaxation by bradykinin of pig coronary artery: NO-dependent and -independent responses.},
  author={C L Cowan and Richard Alan Cohen},
  journal={The American journal of physiology},
  year={1991},
  volume={261 3 Pt 2},
  pages={
          H830-5
        }
}
The role of nitric oxide and guanosine 3',5'-cyclic monophosphate (cGMP) accumulation in the endothelium-dependent relaxation of the porcine coronary artery to bradykinin was investigated by comparing relaxation and cGMP accumulation in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) and methylene blue. Rings were treated with indomethacin to eliminate the effects of prostaglandins. Relaxation to bradykinin of rings contracted with the thromboxane A2 mimetic U-46619 was not… 
Role of Arachidonic Acid
TLDR
Bradykinin-induced relaxation of precontracted, porcine coronary artery (PCA) rings is mediated by distinctly different endothelium-derived relaxing factors depending on the contractile agent used, and it is hypothesized that the non-NO component was mediated by arachidonic acid (AA) or by a non-cyclooxygenase product of AA metabolism.
Phorbol myristate acetate inhibits the bradykinin-induced L-nitro-arginine insensitive endothelium-dependent relaxation of bovine coronary artery.
TLDR
The results suggest that bradykinin-induced endothelium-dependent relaxation of bovine coronary artery depends on both the release of nitric oxide and other endot helium-derived relaxing factor, which is an extremely labile substance, or a non-diffusible factor, as PMA seems to inhibit the production and/or the release the latter substance.
Relationship of arachidonic acid release to porcine coronary artery relaxation.
TLDR
It is suggested that phospholipase C activation and increased intracellular calcium concentration are required for both bradykinin-induced arachidonic acid release and EDHF production in porcine coronary artery.
ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart.
TLDR
The data suggest that the selective enhancement of LV relaxation and rise in coronary flow induced by exogenous bradykinin involve endogenous ATP and the subsequent stimulation of P(2) purinoceptors.
ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart.
TLDR
The data suggest that the selective enhancement of LV relaxation and rise in coronary flow induced by exogenous bradykinin involve endogenous ATP and the subsequent stimulation of P2 purinoceptors.
NO-independent vasodilation to acetylcholine in the rat isolated kidney utilizes a charybdotoxin-sensitive, intermediate-conductance Ca(++)-activated K+ channel.
TLDR
Results suggest that in the rat kidney, Ach, like bradykinin, utilizes a charybdotoxin-sensitive Ca(++)-activated K+ channel of intermediate conductance to elicit vasodilation and that this effect may be dependent on cytochrome P450 activity.
Role of non-nitric oxide non-prostaglandin endothelium-derived relaxing factor ( s ) in bradykinin vasodilation
TLDR
It is concluded that the NO/PGI 2-independent endothelium-dependent vasodilation induced by BK is unlikely to involve a cytochrome P450 arachidonic acid metabolite or an endocannabinoid agonists for the CB 1-receptors.
Effects of Thiopental on Endothelium-Dependent Relaxation in Porcine Coronary Arteries
TLDR
At a clinically relevant concentration of 20 μg/ml thiopental, a significant increase in EDR and a significant reduction in nitric oxide-and prostacyclin-independent relaxation was observed in porcine epicardial coronary arteries.
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